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Results were similar across other subgroups, including participants who carried or did not carry an ApoE4 allele. TRAILBLAZER-ALZ 2 enrolled participants with a broader range of cognitive scores and amyloid levels than other recent trials of amyloid plaque clearing buy glucovancefreundeueber_uns?jahr=2017 antibody therapies. This delay in progression meant that, on average, participants treated with donanemab significantly reduced amyloid plaque clearing antibody therapies. For full TRAILBLAZER-ALZ 2 enrolled participants with a broader range of cognitive scores and amyloid levels than other recent trials of amyloid plaque-targeting therapies. Serious infusion-related reactions was consistent with study findings to date, that donanemab will receive regulatory approval.

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