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This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected. Participants completed their course of treatment with donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes generic Viagra Pills 100 mg from Ohio referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression over the course of. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo. ARIA occurs across the class of amyloid plaque levels regardless of baseline pathological stage of disease.

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FDA for traditional approval was completed last quarter with regulatory action expected by the end of the year. The overall treatment effect of donanemab continued to grow throughout the trial, with the largest differences versus placebo seen at 18 months.

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